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Publications

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  1. Matheus, A., Samer, G., Lu, W. et al. Machine learning polysomnographically-derived electroencephalography biomarkers predictive of epworth sleepiness scale. Sci Rep 13, 9120 (2023). https://doi.org/10.1038/s41598-023-34716-5

  2. Helen Valsamis, Samah Abdul Baki, Jason Leung, Samer Ghosn, Brittany Lapin, Geetha Chari, Izad-Yar Rasheed, Jaehan Park, Vineet Punia, Dileep Nair, Ann Marie Kaniecki, Muhammad Edhi, Carl Y Saab. SARS-CoV-2 slows brain rhythms with more severe effects in younger Individuals. 2022 Jan 12; https://doi.org/10.21203/rs.3.rs-1197196/v1  

  3. Ryan V. Thorpe, Christopher J. Black, David A. Borton, Li Hu, Carl Y. Saab, Stephanie R. Jones. Distinct neocortical mechanisms underlie human SI responses to median nerve and laser evoked peripheral activation. doi: https://doi.org/10.1101/2021.10.11.463545

  4. Davis, K.D., Aghaeepour, N., Ahn, A.H. et al. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nat Rev Neurol 16, 381–400 (2020). https://doi.org/10.1038/s41582-020-0362-2

  5. Adriel Barrios-Anderson, Jared S. Fridley, David A. Borton, Carl Saab. Chapter 9 - Decoding nociception in the spinal cord: Computer modeling and machine learning. 2022. https://doi.org/10.1016/B978-0-12-818662-6.00005-4. ISBN 9780128186626,

  6. Edhi MM, Heijmans L, Vanent KN, Bloye K, Baanante A, Jeong KS, Leung J, Zhu C, Esteller R, Saab CY. Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats. Sci Rep. 2020 Nov 23;10(1):20358. doi: 10.1038/s41598-020-77212-w. PMID: 33230202; PMCID: PMC7683561.

  7. Levitt J, Edhi MM, Thorpe RV, Leung JW, Michishita M, Koyama S, Yoshikawa S, Scarfo KA, Carayannopoulos AG, Gu W, Srivastava KH, Clark BA, Esteller R, Borton DA, Jones SR, Saab CY. Pain phenotypes classified by machine learning using electroencephalography features. Neuroimage. 2020 Dec;223:117256. doi: 10.1016/j.neuroimage.2020.117256. Epub 2020 Aug 29. PMID: 32871260.

  8. Black CJ, Allawala AB, Bloye K, Vanent KN, Edhi MM, Saab CY, Borton DA. Automated and rapid self-report of nociception in transgenic mice. Sci Rep. 2020 Aug 6;10(1):13215. doi: 10.1038/s41598-020-70028-8. PMID: 32764714; PMCID: PMC7413385.

  9. Davis KD, Aghaeepour N, Ahn AH, Angst MS, Borsook D, Brenton A, Burczynski ME, Crean C, Edwards R, Gaudilliere B, Hergenroeder GW, Iadarola MJ, Iyengar S, Jiang Y, Kong JT, Mackey S, Saab CY, Sang CN, Scholz J, Segerdahl M, Tracey I, Veasley C, Wang J, Wager TD, Wasan AD, Pelleymounter MA. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nat Rev Neurol. 2020 Jul;16(7):381-400. doi: 10.1038/s41582-020-0362-2. Epub 2020 Jun 15. PMID: 32541893; PMCID: PMC7326705.

  10. Levitt J, Saab CY. What does a pain 'biomarker' mean and can a machine be taught to measure pain? Neurosci Lett. pii: S0304-3940(18)30824-3, 2018. doi: 10.1016/j.neulet.2018.11.038. [Epub ahead of print] Review. PMID: 30503919

  11. Koyama S, LeBlanc BW, Smith KA, Roach C, Levitt J, Edhi MM, Michishita M, Komatsu T, Mashita O, Tanikawa A, Yoshikawa S, Saab CY. An Electroencephalography Bioassay for Preclinical Testing of Analgesic Efficacy. Sci Rep. 2018 DOI: 10.1038/s41598-018-34594-2.

  12. Levitt J, Nitenson A, Koyama S, Heijmans L, Curry J, Ross JT, Kamerling S, Saab CY. Automated Detection of Electroencephalography Artifacts in Human, Rodent and Canine Subjects using Machine Learning. Journal of Neuroscience Methods 2018, DOI: 10.1016/j.jneumeth.2018.06.014

  13. Koyama S, Xia J, Leblanc BW, Gu JW, Saab CY. Sub-paresthesia spinal cord stimulation reverses thermal hyperalgesia and modulates low frequency EEG in a rat model of neuropathic pain. Scientific Reports 2018, DOI: 10.1038/s41598-018-25420-

  14. LeBlanc BW, Cross B, Smith KA, Roach C, Xia J, Chao YC, Levitt J, Koyama S, Moore CI, Saab CY. Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior. Scientific Reports 2017, DOI: 10.1038/s41598-017-02753-6

  15. Saab CY, Barrett LF. Thalamic Bursts and the Epic Pain Model. Frontiers in Computational Neuroscience 2017, DOI: 10.3389/fncom.2016.00147

  16. Levitt J, Choo HJ, Smith KA, LeBlanc BW, Saab CY. Electroencephalographic frontal synchrony and caudal asynchrony during painful hand immersion in cold water. Brain Research Bulletin 2017, DOI: 10.1016/j.brainresbull.2016.12.011

  17. LeBlanc BW, Bowary PM, Chao YC, Lii TR, Saab CY. Electroencephalographic signatures of pain and analgesia in rats. Pain 2016, DOI: 10.1097/j.pain.0000000000000652

  18. LeBlanc BW, Lii TR, Huang JJ, Chao YC, Bowary PM, Cross BS, Lee MS, Vera-Portocarrero LP, Saab CY. T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain. Pain 2016, DOI: 10.1097/j.pain.0000000000000362

  19. Leblanc BW, Lii TR, Silverman AE, Alleyne RT, Saab CY. Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain. Pain 2014, DOI: 10.1016/j.pain.2014.01.013

  20. Saab CY. Pain-related changes in the brain: diagnostic and therapeutic potentials. Trends in Neuroscience 2012, DOI: 10.1016/j.tins.2012.06.002

  21. Saab C. Visualizing the complex brain dynamics of chronic pain. Journal of Neuroimmune Pharmacology 2013, DOI: 10.1007/s11481-012-9378-8

  22. Shields SD, Cheng X, Gasser A, Saab CY, Tyrrell L, Eastman EM, Iwata M, Zwinger PJ, Black JA, Dib-Hajj SD, Waxman SG. A channelopathy contributes to cerebellar dysfunction in a model of multiple sclerosis. Annals of Neurology 2012, DOI: 10.1002/ana.22665

  23. Iwata M, LeBlanc BW, Kadasi LM, Zerah ML, Cosgrove RG, Saab CY. High-frequency stimulation in the ventral posterolateral thalamus reverses electrophysiologic changes and hyperalgesia in a rat model of peripheral neuropathic pain. Pain 2011, DOI: 10.1016/j.pain.2011.07.011

  24. LeBlanc BW, Zerah ML, Kadasi LM, Chai N, Saab CY. Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy. Neuroscience Letters 2011, DOI: 10.1016/j.neulet.2011.04.077

  25. LeBlanc BW, Iwata M, Mallon AP, Rupasinghe CN, Goebel DJ, Marshall J, Spaller MR, Saab CY. A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia. Neuroscience 2010, DOI: 10.1016/j.neuroscience.2010.02.031

  26. Chang YW, Tan A, Saab C, Waxman S. Unilateral focal burn injury is followed by long-lasting bilateral allodynia and neuronal hyperexcitability in spinal cord dorsal horn. The Journal of Pain 2010, DOI: 10.1016/j.jpain.2009.06.009

  27. Saab CY, Shamaa F, El Sabban ME, Safieh-Garabedian B, Jabbur SJ, Saadé NE. Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation. Journal of Neuroimmunology 2009, DOI: 10.1016/j.jneuroim.2009.01.011

  28. Saab CY, Hains BC. Remote neuroimmune signaling: a long-range mechanism of nociceptive network plasticity. Trends in Neuroscience 2009, DOI: 10.1016/j.tins.2008.11.004

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